Name
Ferulic acid
CAS
1135-24-6
HMDB ID
Synonyms
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoate
(2E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
(E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoate
(E)-3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic acid
(E)-4-Hydroxy-3-methoxycinnamate
(E)-4-Hydroxy-3-methoxycinnamic acid
(E)-4-hydroxy-3-methoxy-Cinnamate
(E)-4-hydroxy-3-methoxy-Cinnamic acid
(E)-Ferulate
(E)-Ferulic acid
3-(4-Hydroxy-3-methoxyphenyl)propenoate
3-(4-Hydroxy-3-methoxyphenyl)propenoic acid
4-Hydroxy-3-methoxycinnamate
4-Hydroxy-3-methoxycinnamic acid
Ferulate
Ferulic acid
trans-4-Hydroxy-3-methoxycinnamate
trans-4-Hydroxy-3-methoxycinnamic acid
trans-Ferulate
trans-Ferulic acid
Molecular formula
C10H10O4
Average molecular weight
194.18
Monoisotopic mass of parent ion
194.0579
Verified Purity
99.9%
Solubility
EtOH 95%: Soluble (50 mg/ml)
Find the volume
mg
g/mol
mM
Find the weight
mM
g/mol
mL
Find the concentration
g/mol
mL
mg
(%)
Chloroform
100
80
60
40
20
0
0
20
40
60
80
100
MeOH
(%)
(%)
H2O
100
80
60
40
20
0
0
20
40
60
80
100
MeOH
(%)
(%)
H2O
100
80
60
40
20
0
0
20
40
60
80
100
DMSO
(%)
H2O (pH)
9
8
7
6
5
4
3
Information
Version
5.0
Status
Detected but not Quantified
HMDB Name
Ferulic acid
Structure
SMILES
COC1=C(O)C=CC(\C=C\C(O)=O)=C1
Description
trans-Ferulic acid is a highly abundant phenolic phytochemical which is present in plant cell walls. Ferulic acid is a phenolic acid that can be absorbed by the small intestine and excreted through the urine. It is one of the most abundant phenolic acids in plants, varying from 5 g/kg in wheat bran to 9 g/kg in sugar-beet pulp and 50 g/kg in corn kernel. It occurs primarily in seeds and leaves both in its free form (albeit rarely) and covalently linked to lignin and other biopolymers. It is usually found as ester cross-links with polysaccharides in the cell wall, such as arabinoxylans in grasses, pectin in spinach and sugar beet, and xyloglucans in bamboo. It also can cross-link with proteins. Due to its phenolic nucleus and an extended side chain conjugation (carbohydrates and proteins), it readily forms a resonance-stabilized phenoxy radical which accounts for its potent antioxidant potential. Food supplementation with curcumin and ferulic acid is considered a nutritional approach to reducing oxidative damage and amyloid pathology in Alzheimer disease (PMID:17127365, 1398220, 15453708, 9878519). Ferulic acid can be found in Pseudomonas and Saccharomyces (PMID:8395165).
Physical Properties
State
Solid
Experimental Properties
Property
Value
Reference
Melting Point
168 - 171 °C
Boiling Point
372.00 to 373.00 °C. @ 760.00 mm Hg (est)
The Good Scents Company Information System
Water Solubility
5970.0 mg/L @ 25 °C (est)
The Good Scents Company Information System
LogP
1.51
HANSCH,C ET AL. (1995)
Biological Properties
Cellular Locations
Cytoplasm
Biospecimen Locations
Blood
Feces
Urine
Tissue Locations
Fibroblasts
Epidermis
Normal Concentrations
Biospecimen
Status
Value
Age
Sex
Condition
Reference
Details
Blood
Detected and Quantified
0.039 +/- 0.020 uM
Adult (>18 years old)
Both
Normal
Blood
Detected and Quantified
0.053 +/- 0.017 uM
Adult (>18 years old)
Male
Normal
Blood
Detected and Quantified
0.031 +/- 0.011 uM
Adult (>18 years old)
Male
Normal
Blood
Detected and Quantified
0.052 +/- 0.02 uM
Adult (>18 years old)
Male
Normal
Blood
Detected and Quantified
0.13 +/- 0.054 uM
Adult (>18 years old)
Male
Normal
Blood
Detected and Quantified
0.027 +/- 0.005 uM
Adult (>18 years old)
Male
Normal
Blood
Detected and Quantified
0.031 +/- 0.008 uM
Adult (>18 years old)
Male
Normal
Blood
Detected and Quantified
0.029 +/- 0.004 uM
Adult (>18 years old)
Male
Normal
Blood
Detected and Quantified
0.157 +/- 0.129 uM
Adult (>18 years old)
Male
Normal
Blood
Detected and Quantified
0-1.581 uM
Adult (>18 years old)
Both
Normal
Blood
Detected but not Quantified
Adult (>18 years old)
Both
Normal
Feces
Detected and Quantified
8.549 +/- 0.978 nmol/g wet feces
Adult (>18 years old)
Both
Normal
Feces
Detected and Quantified
11.793 +/- 6.952 nmol/g wet feces
Adult (>18 years old)
Both
Normal
Feces
Detected and Quantified
13.801 +/- 11.844 nmol/g wet feces
Adult (>18 years old)
Both
Normal
Feces
Detected and Quantified
13.853 +/- 11.0720 nmol/g wet feces
Adult (>18 years old)
Both
Normal
Feces
Detected but not Quantified
Not Specified
Not Specified
Normal
Feces
Detected but not Quantified
Not Specified
Both
Normal
Feces
Detected but not Quantified
Adult (>18 years old)
Both
Normal
Feces
Detected but not Quantified
Adult (>18 years old)
Both
Normal
Feces
Detected but not Quantified
Adult (>18 years old)
Not Specified
Normal
Feces
Detected and Quantified
0.340 (0.00515-5.0210) nmol/g wet feces
Adult (>18 years old)
Both
Normal
Feces
Detected but not Quantified
Adult (>18 years old)
Both
Normal
Urine
Detected and Quantified
36.3 +/- 11.2 umol/mmol creatinine
Adult (>18 years old)
Both
Normal
Urine
Detected and Quantified
0.5 umol/mmol creatinine
Adult (>18 years old)
Both
Normal
Urine
Detected and Quantified
1 umol/mmol creatinine
Adult (>18 years old)
Both
Normal
Urine
Detected and Quantified
1.2 umol/mmol creatinine
Adult (>18 years old)
Both
Normal
Urine
Detected but not Quantified
Adult (>18 years old)
Both
Normal
Urine
Detected and Quantified
0.245 +/- 0.061 umol/mmol creatinine
Adult (>18 years old)
Male
Normal
Urine
Detected and Quantified
0.364 +/- 0.108 umol/mmol creatinine
Adult (>18 years old)
Male
Normal
Urine
Detected and Quantified
0.481 +/- 0.188 umol/mmol creatinine
Adult (>18 years old)
Male
Normal
Urine
Detected and Quantified
3.557 +/- 2.039 umol/mmol creatinine
Children (1 - 13 years old)
Not Specified
Normal
Urine
Detected and Quantified
5.626 +/- 2.711 umol/mmol creatinine
Children (1 - 13 years old)
Not Specified
Normal
Urine
Detected and Quantified
0.80-1.3 umol/mmol creatinine
Adult (>18 years old)
Female
Normal
Urine
Detected and Quantified
0.78-0.98 umol/mmol creatinine
Adult (>18 years old)
Male
Normal
Urine
Detected and Quantified
2.814 umol/mmol creatinine
Adult (>18 years old)
Both
Normal
Urine
Detected and Quantified
0.376-9.270 umol/mmol creatinine
Adult (>18 years old)
Both
Normal
Urine
Detected but not Quantified
Adult (>18 years old)
Both
Normal
Abnormal Concentrations
Biospecimen
Status
Value
Age
Sex
Condition
Reference
Details
Feces
Detected but not Quantified
Adult (>18 years old)
Both
Colorectal Cancer
Feces
Detected but not Quantified
Adult (>18 years old)
Both
Colorectal cancer
Feces
Detected but not Quantified
Adult (>18 years old)
Both
Colorectal cancer
Urine
Detected but not Quantified
Adult (>18 years old)
Both
Hypertension (mild)
Urine
Detected but not Quantified
Adult (>18 years old)
Both
Hypertension (mild)
Urine
Detected and Quantified
4.18 +/- 3.519 umol/mmol creatinine
Children (1 - 13 years old)
Not Specified
Eosinophilic esophagitis
Urine
Detected and Quantified
10.181 +/- 5.131 umol/mmol creatinine
Children (1 - 13 years old)
Not Specified
Eosinophilic esophagitis
Urine
Detected and Quantified
22.261 umol/mmol creatinine
Children (1 - 13 years old)
Not Specified
Gastroesophageal reflux disease
Urine
Detected but not Quantified
Adult (>18 years old)
Both
Bladder cancer
Spectra
Type
Description
View
Predicted GC-MS
splash10-002e-0900000000-d76b7991f2d90cb58bd5
Predicted GC-MS
splash10-00di-6094000000-b805979df23a0d890d7c
Predicted GC-MS
Predicted GC-MS
Predicted GC-MS
Predicted GC-MS
Predicted GC-MS
Predicted GC-MS
Predicted GC-MS
Pathways
Name
SMPDB / Pathwhiz
KEGG
None available